منابع مشابه
Bioaffinity Mass Spectrometry Screening Using Droplet-Based Microfluidics
Bioaffinity mass spectrometry screening is a novel approach using non-denaturing electrospray ionization (ESI) mass spectrometry (MS) in identifying drug leads. This screening technique can detect and preserve noncovalent protein-active drug ligand complexes under different physiological conditions. Although there are many successful screening campaigns employing this technique, the big challen...
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A nano-flow high-resolution screening platform, featuring a parallel chip-based microfluidic bioassay and mass spectrometry coupled to nano-liquid chromatography, was applied to screen animal venoms for nicotinic acetylcholine receptor like (nAChR) affinity by using the acetylcholine binding protein, a mimic of the nAChR. The potential of this microfluidic platform is demonstrated by profiling ...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 2016
ISSN: 1087-0571,1552-454X
DOI: 10.1177/1087057115622605